Public Health
Volume 122, Issue 5 , Pages 458-461 , May 2008

Iodine status and goitre prevalence in nitrate-exposed schoolchildren living in rural Bulgaria

  • Penka D. Gatseva

      Affiliations

    • Department of Hygiene and Ecomedicine, Medical University, 15a Vassil Aprilov Street, 4002 Plovdiv, Bulgaria
    • Corresponding Author InformationCorresponding author. Tel.: +35932602536; fax: +35932636200.
    • ,
  • Mariana D. Argirova

      Affiliations

    • Department of Chemistry and Biochemistry, Medical University, 15a Vassil Aprilov Street, 4002 Plovdiv, Bulgaria

Received 12 February 2007 ,Revised 12 July 2007 ,Accepted 2 September 2007.

References 

  1. Gatseva P, Vladeva S, Pavlov K. Incidence of goiter among children in a village with nitrate contamination of drinking water. Folia Med (Plovdiv, Bulgaria). 1998;40:19–23
  2. Tonacchera M, Pinchera A, Dimida A, Ferrarini E, Agretti P, Vitti P, et al. Relative potencies and additivity of perchlorate, thiocyanate, nitrate, and iodide on the inhibition of radioactive iodide uptake by the human sodium iodide symporter. Thyroid. 2004;14:1012–1019
  3. Eskiocak S, Dundar C, Basoglu T, Altaner S. The effects of taking chronic nitrate by drinking water on thyroid function and morphology. Clin Exp Med. 2005;5:66–71
  4. Tajtakova M, Semanova Z, Tomkova Z, Szokeova E, Majoros J, Radikova Z, et al. Increased thyroid volume and frequency of thyroid disorders signs in schoolchildren from nitrate polluted area. Chemosphere. 2006;62:559–564
  5. Urbansky ET. Perchlorate as an environmental contaminant. Environ Sci Pollut Res. 2002;9:187–192
  6. De Groef B, Decallonne BR, Van der Geyten S, Darras VM, Bouillon R. Perchlorate versus other environmental sodium/iodide symporter inhibitors: potential thyroid-related health effects. Eur J Endocrinol. 2006;155:17–25
  7. Gopina G. Contamination of groundwater with nitrates. In:  Vasilev K editors. Manual for safety application of pesticides and fertilizers around water sources. Sofia: Medicine and Sport; 1994;p. 59–70[in Bulgarian]
  8. International Council for the Control of Iodine Deficiency Disorders, WHO, UNICEF. Assessment of iodine deficiency disorders and monitoring their elimination. A guide for programme managers. 2nd ed. Geneva: WHO; 2001.
  9. Dunn JT, Crutchfield HE, Gutekunst R, Dunn AD. Methods for measuring iodine in urine. A joint publication of ICCIDD, UNICEF, and WHO. The Netherlands: ICCIDD; 1993. p. 18–51.
  10. Medina VF, Larson SL, Extine B, Bednar A. Perchlorate analysis using solid-phase extraction cartridges. J Chromatogr Sci. 2005;43:195–200
  11. Delange F, de Benoist B, Alnwick D. Risks of iodine induced hyperthyroidism after correction of iodine deficiency disorders by iodized salt. Thyroid. 1999;6:545–556
  12. Zimmermann MB, Ito Y, Hess SY, Fujieda K, Molinari L. High thyroid volume in children with excess dietary iodine intakes. Am J Clin Nutr. 2005;81:840–844

PII: S0033-3506(07)00292-2

doi: 10.1016/j.puhe.2007.09.001

Public Health
Volume 122, Issue 5 , Pages 458-461 , May 2008

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